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KMID : 0364820220580030109
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Korean Journal of Microbiology
2022 Volume.58 No. 3 p.109 ~ p.119
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Multi-faceted regulatory roles of EIIANtr, the final phosphate receptor of nitrogen-related phosphotransferase system
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Park Chan-Sau
Lee Eun-Jin
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Abstract
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The nitrogen-related phosphotransferase system (PTSNtr) is a secondary phosphorelay cascade system present in many Gramnegative bacteria. The primary sugar phosphotransferase (sugar- PTS) system has various physiological functions in bacteria based on carbon nutrients and their metabolites. Similarly, regulatory mechanisms of the PTSNtr also vary depending on the species. Recently, several studies have reported on the global regulation mechanism of EIIANtr (encoded by ptsN), the final phosphate receptor of PTSNtr, involved in nitrogen/carbon metabolism, K+ concentration regulation, and virulence regulation.
Depending on the diversity of strains with the corresponding systems, different phenotypes have been observed from regulation by EIIANtr. Furthermore, since some of its regulatory mechanisms are yet to be discovered, the purpose of this review is to organize various phenotypes through the regulation of EIIANtr based on environmental conditions across species, with updating recent findings on its mechanism.
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KEYWORD
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EIIANtr, nitrogen-related phosphotransferase system (PTSNtr), pleiotropic effect, ptsN
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